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Group Member: Thomas Krausgruber

Contact Details

  • E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Phone: +43 1 40160 70066

Research Interests

  • I am interested in cell plasticity and which environmental cues induce cell adaptation to different tissues but also which transcription factors ultimately enforce these processes.

Academic Employment

  • 2015 – present: Post-doctoral fellow with Christoph Book at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • 2012 – 2015: Post-doctoral fellow with Fiona Powrie at the Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, UK; working on the role of IL-33 in promoting regulatory T cell function in the intestine.
  • 2011 – 2012: Post-doctoral fellow with Irina Udalova at the Kennedy Institute of Rheumatology, Imperial College London, UK; working on IRF5-mediated inhibition of IL-10 production.
  • 2007 – 2011: PhD student under the supervision of Irina Udalova at the Kennedy Institute of Rheumatology, Imperial College London, UK; working on the role of the transcription factor IRF5 in macrophage polarization.

Academic Degrees

  • Aug. 2011: PhD in Immunology from Imperial College London, UK
  • Aug. 2007: MSc in Genetic from University of Salzburg, Austria
  • Feb. 2006: BSc in Genetics and Molecular Biology from University of Salzburg, Austria

Scholarships and Awards

  • 2014: MinION Access Program by Oxford Nanopore Technologies Ltd
  • 2008: Milstein Travel award from ICIS (former ISICR)
  • 2007: Kennedy Trust Prize Studentship (4 year PhD training program)
  • 2007: Merit scholarship from Salzburg University for MSc thesis

Publications

  • Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR and Powrie F (2015). Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis. Immunity 43: 187-199.
  • Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE and Maloy KJ (2015). Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3 Treg cell function in the intestine. Mucosal Immunol.
  • Schiering C*, Krausgruber T*, Chomka A, Frohlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Lohning M, Belkaid Y, Fallon PG and Powrie F (2014). The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature 513: 564-568. (*equal contributors)
  • Verjee LS, Verhoekx JS, Chan JK, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood KS and Nanchahal J (2013). Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target. Proc Natl Acad Sci U S A 110: E928-937.
  • Eames HL, Saliba DG, Krausgruber T, Lanfrancotti A, Ryzhakov G and Udalova IA (2012). KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages. Immunobiology 217: 1315-1324.
  • Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M and Udalova IA (2011). IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 12: 231-238.
  • Goh FG, Thomson SJ, Krausgruber T, Lanfrancotti A, Copley RR and Udalova IA (2010). Beyond the enhanceosome: cluster of novel kappaB sites downstream of the human IFN-beta gene is essential for lipopolysaccharide-induced gene activation. Blood 116: 5580-5588.
  • Krausgruber T, Saliba D, Ryzhakov G, Lanfrancotti A, Blazek K and Udalova IA (2010). IRF5 is required for late-phase TNF secretion by human dendritic cells. Blood 115: 4421-4430.
  • Goh FG, Piccinini AM, Krausgruber T, Udalova IA and Midwood KS (2010). Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation. J Immunol 184: 2655-2662.
  • Thomson SJ, Goh FG, Banks H, Krausgruber T, Kotenko SV, Foxwell BM and Udalova IA (2009). The role of transposable elements in the regulation of IFN-lambda1 gene expression. Proc Natl Acad Sci U S A 106: 11564-11569.

Miscellaneous

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