Instructions: Use the mouse wheel to zoom in and out. Click and drag on individual nodes in the network to move them. Click and drag on the network pane to shift the view and move the entire network. Select a node (by clicking it or using the dropdown menu) to highlight only this node and those immediately connected to it.

Gene regulatory networks were inferred for three LCH cell subsets (LCH-S1, LCH-S12, LCH-S11), based on single-cell transcriptome and ATAC-seq data, and the key regulators identified by enrichment analysis. Nodes in the network correspond to the enriched transcription factors as well as their putative target genes (based on sequence proximity and chromatin 3D structure). Node size is proportional to both gene expression level and node out-degree (i.e., number of outgoing connections from the transcription factor) in the respective LCH subset. Edge colours indicate the module of the corresponding peak, and edge visibility is proportional to chromatin accessibility. The network layout was automatically generated using the igraph package.